TechSurge: Deep Tech Podcast
Exploring topics at the intersection of emerging technology, geopolitics, and business.
Hosted by Celesta Capital.
The TechSurge: Deep Tech VC Podcast shares the latest insights directly from legendary Silicon Valley leaders, daring new founders, and visionary technologists.
Join us as we examine the factors shaping the next major technology cycle shift of AI, examine emerging global tech hubs, and analyze where investment dollars are flowing next.
Each discussion delves into the intersection of technology advancement, market dynamics, and the founder journey, offering insights into the vast opportunities and complex challenges ahead.
For entrepreneurs, investors, or anyone interested in where we're headed next, this is your guide to understanding the technologies and companies poised to transform the future.
Governing AI Before It Outpaces Us: Safety for Critical Infrastructure
As generative AI systems move from novelty to infrastructure, questions of safety, trust, and governance are becoming urgent. In this episode of TechSurge, host Sriram Viswanathan is joined by Dr. Rumman Chowdhury, CEO of Humane Intelligence PBC and responsible AI Pioneer, about what AI safety really means and why the industry may be focusing on the wrong problems.
Rumman argues that the most overlooked lever in AI development is evaluation. While companies emphasize model training and capabilities, far less attention is paid to how systems are assessed in real-world contexts, who defines “good,” what risks are measured, and how societal impacts are accounted for at scale. She distinguishes between technical assurance and broader sociotechnical risk, from misinformation and bias to over-reliance and erosion of institutional trust.
Drawing on her experience at Twitter (X) and in global policy circles, Rumman highlights a fundamental governance gap: unlike finance, aviation, or healthcare, AI lacks a mature, independent ecosystem of auditors and evaluators. Today, the same companies building AI systems often define what counts as harm. She also challenges the belief that stronger guardrails alone will solve the problem, noting that cultural context, language differences, and human behavior complicate any notion of “neutral” or fully objective AI.
Rather than focusing solely on speculative existential threats, Rumman urges attention to the harms already visible from AI-enabled misinformation to mental health risks and shifts in how younger generations relate to knowledge and authority. The future of AI, she suggests, will be determined not just by technological breakthroughs, but by whether we build credible systems of accountability, evaluation, and global cooperation around them.
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Driven both by surging demand and rapid technology advancements, an emerging area of health innovation called “bioconvergence” is driving improvements in human health and sustained interest from investors. This episode will explore these new applications merging engineered technologies with scientific disciplines, including in diagnostics, therapeutics, and elsewhere.
Nobel Laureate Dr. Jim Rothman, Dr. Melanie Mathieu of Prellis Biologics, and Daniel Dornbusch of Excision join host Michael Marks for an in-depth discussion covering advancements in CRISPR technology, the role of AI in drug discovery, the future of personalized medicine, and much more.

Legendary technology founder and venture investor Vinod Khosla joins host Michael Marks for a wide-ranging discussion on the future of AI, major tech cycles, the importance of being honest with founders, and much more. Vinod shares his predictions for the next 25 years of technology advancement and how we should be assessing the risks and benefits as the adoption of artificial intelligence continues to accelerate.
Celesta Capital is a global deep tech venture firm enabling visionary founders at the forefront of scientific and engineering breakthroughs.
Celesta's team has spent decades founding, leading, and scaling global technology businesses, collectively founding more than 40 companies. We understand how to partner with founders to help turn prototypes into powerhouses.
From semiconductors and systems to breakthrough biology, we seek out the physics‑defying, code‑rewriting breakthroughs that will power the next decade of technology advancement.
